Some of these characters were temporarily merged in the same universe in the 2015 comic book series Secret Wars as a part of the Spider-Man family. Some of these characters appeared in Spider-Man: Into the Spider-Verse. Originally, these characters were depicted as separate from each other, but they have crossed over together in storylines like ' Spider-Verse', 'Web Warriors', and Spider-Geddon, in teams such as Spider-Army and Web Warriors, where the many different versions of Spider-themed characters are the major protagonists of the storyline. Popular examples include characters such as talking animal parodies like Spider-Ham, an alternate future version named Miguel O'Hara, a daughter of Peter Parker named Mayday Parker in the MC2 universe, a different take on Peter Parker in the Great Depression era, the Ultimate version of Peter Parker and his successor, Miles Morales, along with a variant of Spider-Man where Peter's supporting character, Gwen Stacy, becomes Spider-Woman instead of Parker. Outside of the mainstream universe, there are different incarnations of Spider-Man in alternate universes. Within the mainstream Marvel Universe there have been characters that have taken the mantle such as Ben Reilly, Mac Gargan and Doctor Octopus. The original and most well known is Peter Parker created by Stan Lee and Steve Ditko originating from the Earth-616 universe. ' Spider-Man' is the name of multiple comic book superheroes from the Marvel Comics Multiverse.

The many versions of Spider-themed characters as seen in the Spider-Geddon storyline.

Spiderman deadpool 1 variant